Anchored by Jake Tapper, The Lead airs at 4 p.m. ET on CNN.
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Seventy thousand people have already been killed in Syria's two-year long civil war, and now there are reports that forces there have started using chemical weapons. As of now these reports are unconfirmed, it's not clear who fired them - each side blames the other.
If the reports are substantiated, "this is a game-changer and we'll act accordingly," said White House Chief of Staff Denis McDonough.
"This is something we take very, very seriously. We had teams up working on this overnight, as you might suspect, and we'll continue to trace this," McDonough continued.
For more of our interview, click on the video.