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(CNN) - Dangerously cold temperatures are predicted throughout the country this weekend, with temperatures dropping to near -50 Fahrenheit in some parts of the Midwest - that includes the Ice Bowl at Lambeau Field, where the Green Bay Packers are set to host the San Francisco 49ers Sunday.
People face significant risks when the temperatures drop that low. The two big ones are hypothermia and frostbite, says CNN chief medical correspondent Dr. Sanjay Gupta.
With the temperatures forecast for Sunday's game, "in as little as 15 minutes, you can start to develop frostbite, so just an exposed part of the skin can develop that problem pretty quickly," said Gupta.
"I personally probably would not go to a game like that," said Gupta. "It's going to be probably not that pleasant for people who are out there the entire time."
If you do go, loosely layer clothes to keep warm air trapped inside, wear a hat because 20% of body heat is lost through the head, and make sure you eat a big meal because eating helps generate body heat, whereas drinking alcohol has the opposite effect, says Gupta.
Also, head indoors when possible.
"Get inside to the heated bathroom areas, outside of the wind chill in particular, every so often," said Gupta.
"I'm not sure that I would go, but I think you can do it safely if you do go," the doctor says.